| 英文名称 |
Anti-ALDH2 Monoclonal Antibody |
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| 宿主 |
Mouse |
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| 别名 |
ALDH-E2;ALDHI;ALDM |
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| 稀释比例 |
WB 1:1000. |
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| 蛋白分子量 |
56kDa |
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| Gene ID |
217 |
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| 保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
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| 储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 纯化方法 |
Affinity purification |
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| 亚型 |
IgG1 |
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| 免疫原 |
Purified recombinant human ALDH2 protein fragments expressed in E.coli |
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| 性状 |
液体 |
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| Public Immunogen Range |
Purified recombinant human ALDH2 protein fragments expressed in E.coli |
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| 亚细胞定位 |
Mitochondrion matrix |
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| Swiss Prot |
P05091 |
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| 克隆号 |
8D4-D6-D11 |
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| 克隆类型 |
Monoclonal Antibody |
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| 背景资料 |
This protein belongs to the aldehyde dehydrogenase family of proteins.Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism.Two major liver isoforms of aldehyde dehydrogenase,cytosolic and mitochondrial,can be distinguished by their electrophoretic mobilities,kinetic properties,and subcellular localizations.Most Caucasians have two major isozymes,while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme.A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme.The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer.This gene encodes a mitochondrial isoform,which has a low Km for acetaldehydes,and is localized in mitochondrial matrix.Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq,Mar 2011] |
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| 应用 |
WB |
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| 交叉反应 |
Human Mouse Rat Monkey Hamster |
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