| 英文名称 |
Anti-AKT1/AKT2/AKT3 Polyclonal Antibody |
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| 宿主 |
Rabbit |
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| 稀释比例 |
WB 1:500-1000. |
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| 蛋白分子量 |
48/51/54/56kDa |
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| Gene ID |
207/208/10000 |
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| 保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
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| 储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
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| 纯化方法 |
Affinity purification |
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| 亚型 |
IgG |
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| 免疫原 |
A synthetic peptide of human AKT1/AKT2/AKT3 |
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| Swiss Prot |
P31749; P31751; Q9Y243 |
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| 克隆类型 |
Polyclonal Antibody |
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| 背景资料 |
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. |
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| 应用 |
WB |
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| 交叉反应 |
Human Mouse |
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