宿主 |
Mouse |
英文名称 |
Anti-AIFM1 Monoclonal Antibody |
别名 |
AIF;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8 |
稀释比例 |
WB 1:1000. ICC 1:200. |
蛋白分子量 |
67kDa |
Gene ID |
9131 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG2a |
免疫原 |
Purified recombinant human AIFM1 protein fragments expressed in E.coli. |
性状 |
液体 |
亚细胞定位 |
Cytoplasm Mitochondrion inner membrane Mitochondrion intermembrane space Nucleus perinuclear region |
Swiss Prot |
O95831 |
克隆号 |
8H1-B10-A12 |
克隆类型 |
Monoclonal Antibody |
背景资料 |
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. |
应用 |
WB IF |
交叉反应 |
Human |